Asymmetric Synthesis of Enantiopure Pyrrolidines by C(sp ³ )?H Amination of Hydrocarbons

The asymmetric synthesis of enantiopure pyrrolidines is reported via a streamlined strategy relying on two sequential C?H functionalizations simple hydrocarbons. first step regio- and stereoselective catalytic nitrene insertion. Then, subsequent diastereoselective cyclization involving 1,5-hydrogen atom transfer (HAT) from N-centered radical leads to the formation that can then be converted their free NH-derivatives.